Abstract
One pot three-component PEG-SO 3H catalyzed reaction of 4-(Pyridin-4-yl)benzaldehyde and triethyl phosphite with various primary amines afforded α-aminophosphonates with high yields by the Kabachnik–Field’s reaction. These new structurally diversified set of α-aminophosphonates ( 4a–j) were evaluated for their anti-tumor activity on human chronic myeloid leukemia cells ( K 562), human colon carcinoma cells ( Colo 205) along with non-cancerous human embryonic kidney cells ( HEK 293). They showed moderate activity on both cancerous cells and non-cancerous cells.
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