Abstract
We have used poly(ethylene glycol)-functionalized N-heterocyclic carbene ligands, 1-(methoxy PEG)-3-methylimidazolium iodides together with Pd(OAc)2 as efficient catalysts for the Suzuki reaction in water. The best catalytic system generated in situ from Pd(OAc)2, mPEG16MeImI, and K2CO3 is able to mediate the Suzuki coupling of a series of aryl boronic acids and aryl halides, except for deactivated aryl chlorides, in good to almost quantitative yields in water within 6 h. After extraction of the product, the catalyst containing mPEG n MeImI phase could be recycled for five times without significant loss of activity. Three PEG-modified NHC ligands with different PEG chain lengths (mPEGnMeImI, n = 7, 12, and 16) were used for Pd-catalyzed Suzuki reactions in water. The best catalytic system generated in situ from Pd(OAc)2, mPEG16MeImI, and K2CO3 is able to mediate the Suzuki coupling of a series of aryl boronic acids and aryl halides, except for deactivated aryl chlorides, in good to almost quantitative yields in water within 6 h. After extraction of the product, the catalyst containing mPEG n MeImI phase could be recycled for five times without significant loss of activity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
