Abstract
pH responsive prodrug nanoparticles (PEG-DOX) were prepared by attaching free Doxorubicin ( DOX) onto the amphipathic polyethylene glycol-aldehyde (PEG-CHO). The hydrophobic core of PEG-CHO enabled free DOX to be attached, while the hydrophilic outer layer of the carrier enabled the water solubility of the entire structure. This nanocarrier enabled a greater carrying capacity than free DOX, making its circulation time longer. The prodrug remained stable within neutral pH, ensuring its prolonged circulation time, but disassembled rapidly when reaching in the acidic environment of tumor tissues to release the free DOX. The newly designed nanocarriers have the potential to be applied clinically as a future DOX formulation in cancer chemotherapy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
