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Abstract
The study outlined a standardized double emulsion method for simple poly(ethylene glycol)-block-poly(lactic-co-glycolic acid) (PEG-b-PLGA) nanoparticle (NP) synthesis. The PEG-b-PLGA NP was also used for entrapment of geraniin as a simple model system for phytochemical delivery. PEG-b-PLGA NPs were prepared using the double emulsion method. The yields and particle sizes of PEG-b-PLGA NPs obtained with and without encapsulation of geraniin were 57.6% and 134.20 ± 1.45 nm and 66.7% and 102.70 ± 12.36 nm, respectively. High-performance liquid chromatography of geraniin that was extracted from Phyllanthus watsonii was detected at 64 min. Geraniin burst release began at 40 min and fully released at 3 h. PEG-b-PLGA NP was non-cytotoxic, while cytotoxicity of geraniin was dose dependant towards normal human epithelial colon cells, CCD 841 CoN cells.
Highlights
The shift from micro- to nano-sized particles is one of the recent advances in biomedical applications.Nanoparticles (NPs) offer numerous advantages in the pharmaceutical and biomedical industries.For example, the physical and chemical characteristics of NPs can mask poorly water-soluble drugs, alter the pharmacokinetics of a drug, reduce the immunogenicity of a drug by increasing its half-life, produce a target-specific drug that reduces side effects, and increase the bioavailability to shorten metabolism of the drug [1].Polymers with amphiphilic properties are ideal for drug delivery
The estimated percentage yield of Poly(ethylene glycol) (PEG)-b-Poly(lactic-co-glycolic acid) (PLGA) NPs was ~66.7%, and that of PEG-b-PLGA NPs encapsulated with geraniin was 57.6%
PEG-b-PLGA NPs and PEG-b-PLGA NPs encapsulated with geraniin were of optimal size for drug delivery, with values of 102.7 ± 12.36 nm and 134.2 ± 1.45 nm, respectively
Summary
The shift from micro- to nano-sized particles is one of the recent advances in biomedical applications.Nanoparticles (NPs) offer numerous advantages in the pharmaceutical and biomedical industries.For example, the physical and chemical characteristics of NPs can mask poorly water-soluble drugs, alter the pharmacokinetics of a drug, reduce the immunogenicity of a drug by increasing its half-life, produce a target-specific drug that reduces side effects, and increase the bioavailability to shorten metabolism of the drug [1].Polymers with amphiphilic properties are ideal for drug delivery. The shift from micro- to nano-sized particles is one of the recent advances in biomedical applications. Nanoparticles (NPs) offer numerous advantages in the pharmaceutical and biomedical industries. The physical and chemical characteristics of NPs can mask poorly water-soluble drugs, alter the pharmacokinetics of a drug, reduce the immunogenicity of a drug by increasing its half-life, produce a target-specific drug that reduces side effects, and increase the bioavailability to shorten metabolism of the drug [1]. Polymers with amphiphilic properties are ideal for drug delivery. (PLGA) is a biodegradable polymer that has been approved by the US Food and Drug Administration (FDA) for use in drug delivery systems. PLGA is known for its biocompatibility, bioavailability, enhancement of drug content specificity, and immunosuppressive potential [2].
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