Abstract
PEG-200, a biodegradable, non-toxic, economical, easily available, robust and recyclable solvent mediated one-pot three-component reaction for synthesis of diverse array of functionalised N-amino-3-cyano-2-pyridone by the reaction of aldehydes, cyanoacetohydrazide and malononitrile or ethyl cyanoacetate has been demonstrated. This protocol is a cascade type reaction that includes the series of Knoevenagel condensation, Michael addition, intramolecular cyclisation, imine-enamine tautomerization and oxidative aromatization. Utilization of biodegradable greener solvent without any supplementary catalyst, shorter reaction time than previously reported protocols, easily accessible synthons, mild reaction condition and easy purification of desired products are the foremost advantages of these protocols.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
