PEFR and FEF<sub>25-75</sub> in type 2 diabetes mellitus and their relationships with its duration

Abstract

Background: Diabetes mellitus is a major public health problem with increasing incidence worldwideand long term complications of various organs including lungs. The magnitude of the complicationsof this disease is related to its duration. Objective: To observe PEFR and FEF25-75 in type 2 diabeticmale and their relationship with duration of the disease. Methods: This cross sectional study wascarried out in the Department of Physiology, BSMMU, Dhaka, from 1st July 2007 to 30th June 2008 on60 type 2 diabetic, non smoker, male of 40-60 years old. For comparison, 30 age, BMI and socioeconomicstatus matched apparently healthy non diabetic subjects were also studied. Based on the duration ofdisease, diabetic patients were divided into B1 (5-10 years) and B2 (10-20 years). PEFR and FEF25-75 ofall the subjects were measured by an electronic spirometer. Data were analyzed by One way ANOVA,Unpaired Student's 't' and Pearson's correlation coefficient tests. Results: The mean percentage ofpredicted values of PEFR and FEF25-75 in non diabetic male were within normal ranges. But, both theparameters were significantly (p<0.001) lower in both the groups of type 2 diabetic male compared tothose of non diabetic male. Again, the PEFR and FEF25-75 were lower in the patients of longer durationcompared to those of shorter duration but the differences were not significant. However, PEFR wasnegatively correlated and FEF25-75 was positively correlated with shorter duration of diabetes and therelationships were nonsignificant. On the other hand, both the parameters were negatively correlatedwith longer duration of diabetes while only PEFR showed significant (p<0.01) relationship. Conclusion:The PEFR and FEF25-75 may be lower in type 2 diabetic male, which are inversely related to theduration of the disease.Key words: PEFR; FEF25-75; Diabetes Mellitus.DOI: 10.3329/jbsp.v5i1.5413J Bangladesh Soc Physiol. 2010 June; 5(1): 14-19