Abstract
Cryptococcus neoformans is an opportunistic fungal pathogen that is ubiquitous in the environment. It causes a deadly meningitis that is responsible for over 180,000 deaths worldwide each year, including 15% of all AIDS-related deaths. The high mortality rates for this infection, even with treatment, suggest a need for improved therapy. Unique characteristics of C. neoformans may suggest directions for drug discovery. These include features of three structures that surround the cell: the plasma membrane, the cell wall around it, and the outermost polysaccharide capsule. We review current knowledge of the fundamental biology of these fascinating structures and highlight open questions in the field, with the goal of stimulating further investigation that will advance basic knowledge and human health.
Highlights
Cryptococcus neoformans is an opportunistic fungal pathogen that causes severe infection of the central nervous system
Anchoring it, lies the fungal cell wall. This complex structure surrounds the plasma membrane and helps the cell withstand environmental challenges such as osmotic and mechanical stress. It is composed of glucans, chitin, chitosan, and glycosylated proteins (Gow et al 2017)
Melanin pigment associated with the cell wall further helps C. neoformans resist environmental stress and antifungal drug toxicity
Summary
Cryptococcus neoformans is an opportunistic fungal pathogen that causes severe infection of the central nervous system. These consist of three concentric structures: the capsule, cell wall, and plasma membrane (Fig. 1A, left). Melanin pigment associated with the cell wall further helps C. neoformans resist environmental stress and antifungal drug toxicity.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
