Abstract
Intractable epilepsy accounts for approximately 30% cases of epilepsy worldwide, and continues to pose a medical challenge even today. Several studies have demonstrated the strong anti-epileptic influence of rapid eye movement (REM) sleep in humans, some researchers even claiming it as the most potent anti-epileptic state in human sleep–wake cycle. A reduction of REM sleep is a common feature reported in various forms of intractable epilepsy. Several studies have reported reduction to total disappearance of even the severe EEG abnormalities in West syndrome during REM sleep suggesting an explorable relation between the reduction of REM sleep and severity/intractability of seizures.
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