Pediatrik Psöriyazis Hastalarında Nötrofil/Lenfosit Oranı, Platelet/Lenfosit Oranı ve Ortalama Platelet Hacminin Değerlendirilmesi: Tanımlayıcı Bir Çalışma

Abstract

Objective: Psoriasis is a chronic inflammatory disease and clinical symptoms start during childhood in about one third of the patients. The aim of this study is to investigate the existence of inexpensive and easily applicable laboratory parameters that can be used in the evaluation of disease activity and severity in childhood psoriasis. Material and Methods: This retrospective study included 72 psoriatic patients who admitted to the dermatology outpatient clinic of a tertiary university hospital within one year and 45 healthy controls under 18 years of age. Demographic and clinical data were recorded from files. Erythrocyte sedimentation rate (ESR), C-reactive protein, white blood cell (WBC), lymphocyte, neutrophil, platelet counts, mean platelet volume (MPV) value were recorded and neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio were calculated and noted. Results: The study included totally 117 children; 72 (45 females, 27 males) patients and 45 (23 females, 22 males) controls. In the patient group, 42 (58.3%) children had plaque type and 30 (41.7%) children had guttate type psoriasis. ESR, WBC, neutrophil counts, MPV and NLR values were significantly higher in the patient group than the control group (p<0.001, p<0.001, p<0.001, p<0.001, p=0.002, respectively). NLR was found to be higher in plaque type psoriatic patients compared to control group (p=0.005). Conclusion: WBC, neutrophil count, MPV and NLR values can be alternative parameters for the assesment of the disease activity in pediatric psoriasis.