Abstract
Aim: Corpus callosum (CC) is a white matter structure and it is the largest interhemispheric commissure that connects the brain hemispheres. The morphology of CC can be affected by congenital and acquired diseases, sex, age, and hand selection. This study aims to investigate morphometric features of CC by age and gender.Material and Methods: Thickness of all corpus callosum segments and length of the long axis of the CC of the healthy pediatric population were measured via magnetic resonance imaging (MRI) from the midsagittal line where the septum pellucidum and massa intermedia can be monitored. A total of 240 participants (120 males and 120 females) were divided into four age groups; 0-2 age group, 3-6 age group, 7-11 age group, and 12-17 age group and thickness of the five segments of the CC (rostrum, genu, body, isthmus, splenium) and anterior-posterior length of the CC were measured. Results: Thicknesses of four segments that included genu, body, isthmus, and splenium (except the rostrum) and length of the long axis of CC increased significantly with age in both genders. However, when we evaluated all participants without gender discrimination, the thickness of all segments of CC and length of the long axis are observed to increase significantly. Conclusion: The obtained data from the healthy pediatric population will help differentiate the abnormal morphometric changes of CC due to congenital and acquired diseases.
Highlights
MATERIAL AND METHODSCorpus callosum (CC) is a crescent-shaped white matter structure extending from anterior to posterior, approximately 10 cm long, located deep in the interhemispheric fissure [1]
Since CC is a white matter structure composed of myelinated nerve fibers, its development from the fetal period to the adult period has always been a matter of curiosity
There are studies in the literature regarding the development of CC in childhood, the relationship of CC with the development of cognitive functions in adolescence, the relationship of CC anomalies with neuropsychiatric diseases and the differences of CC between genders [6, 12,13,14,15]
Summary
Corpus callosum (CC) is a crescent-shaped white matter structure extending from anterior to posterior, approximately 10 cm long, located deep in the interhemispheric fissure [1]. Based on the former histological findings, CC consists of four sections: rostrum, genu, body, splenium. These structures connect different areas of the cortex [2]. The body in the middle section of CC provides the connections between the precentral and premotor region of the frontal lobe and the parietal lobe and temporal lobe. Isthmus is named for the narrowest region between the body and the splenium part of CC [5]
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