Abstract
Introduction: Pediatric Germ cell tumors are rare disease in pediatric and adolescent age group. Germ cell tumors are the most frequently found malignancies which are highly chemo sensitive. GCTs are curable if diagnosed and treated adequately even in resources poor setting in resource constraints countries like Nepal.
 Objective: To study the clinic pathological profile and treatment outcome of Pediatrics Germ cell tumors (GCTs) among children and adolescent group seeking treatment at B.P. Koirala Memorial Cancer Hospital (BPKMCH), Nepal.
 Methodology: Descriptive study was done at BPKMCH Nepal. All available case records of pediatric and adolescent girls diagnosed to have GCTs from 2002 to 2011 were collected and analyzed in terms of age, clinical features, malignancy types, treatment modalities and outcome.
 Results: Total 70 girls were with female gynecological malignancy. There are 46 (76.66%) with ovarian malignancies. Among the ovarian cancers, 42 had malignant germ cell cancer (91.3%) among all ovarian malignancies which are enrolled in the study. The commonest presentation was abdominal distension and pain in70%. Onset of symptoms ranged from three days to 730 days (mean 95 days). Disease stage at presentation was early stage 18 (30%) and advanced disseminated disease 42 (70%). In treatment modality, 8 (13.33%) underwent fertility sparing surgery only, 21(35%) underwent chemotherapy only and 31(51.66%) underwent multimodality treatment. 82.5% patients who were completed recommended treatment were cured.
 Conclusion: Malignant germ cell cancer is the commonest ovarian malignancies among pediatric and adolescent girls. Early presentation and prompt appropriate treatment would offer chances of cure even with preservation of fertility.
Highlights
Pediatric Germ cell tumors are rare disease in pediatric and adolescent age group
The aim and objective of this study is to find out the clinic-pathological profile of pediatric Germ cell tumors and their treatment outcome among pediatric and adolescent group (
Total of 53 children and adolescent girls were diagnosed as germ cell tumors which was 3.25%
Summary
Pediatric Germ cell tumors are rare disease in pediatric and adolescent age group. Germ cell tumors are the most frequently found malignancies which are highly chemosensitive. GCTs are curable if diagnosed and treated adequately even in resources poor setting in resource constraints countries like Nepal. Germ cell tumors are rare in pediatric and adolescent girls among all malignancies. Germ cell tumors (GCTs) are the most frequently found ovarian malignancies in pediatric and adolescent age group, which are highly chemo-sensitive. GCTs are a rare and heterogeneous group of tumors that account for 3% of pediatric cancers. GCTs are assumed to originate from the primordial germ cells in growing embryo in embryogenesis, which migrate along the midline of the body to the gonadal ridge.[7,8,9] The GCTs in extra gonadal site are believed to form due to failure of proper migration to gonad.[10]
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