Abstract
Stevens–Johnson syndrome and toxic epidermal necrolysis are rare severe blistering skin reactions triggered by medications or infections. Over the last 5 to 10 years, a number of important publications have advanced understanding of these diseases and their response to treatment. Importantly, a subset of patients with disease triggered by infection has been identified as having Mycoplasma pneumoniae–induced rash and mucositis, suggesting a reconsideration of the diagnostic paradigm. We present an update on pediatric Stevens–Johnson syndrome and toxic epidermal necrolysis in the broader context of cutaneous adverse drug reactions and focus on challenges and recent advances in diagnosis, management, and prevention.
Highlights
Skin reactions are among the most common types of adverse reactions to medications in children, accounting for 36% of any adverse drug reaction (ADR)[1]
The diagnosis and treatment of cutaneous ADRs in children are challenging for several reasons
Triggers of severe cutaneous adverse drug reaction (cADR), such as Stevens–Johnson syndrome (SJS), are different in adults and children; medications more often are implicated in adults and infections more commonly cause SJS in children[3]
Summary
Faculty Reviews are review articles written by the prestigious Members of Faculty Opinions. The articles are commissioned and peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. 1. Teresa Bellón, La Paz Hospital Health Research Institute-IdiPAZ, Madrid, Spain. Any comments on the article can be found at the end of the article
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