Abstract
Pediatric Pneumonia Death Caused by Community-acquired Methicillin-Resistant<i>Staphylococcus aureus</i>, Japan
Highlights
To the Editor: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which carries genes for Panton-Valentine leukocidin (PVL), has become a major concern worldwide [1,2,3]
Several types of CA-MRSA clones exist, e.g., CA-MRSA belonging to multilocus sequence type (ST) 1 and ST8, which have been major clones in North America; CA-MRSA belonging to ST80, which has been a major clone in Europe; and CA-MRSA belonging to ST30, which is distributed worldwide, including Japan [2,8]
MRSA carrying the PVL gene comprises 0.1% of MRSA isolated in hospitals in Japan [9].We describe a fatal case of pediatric pneumonia and septic shock from CA-MRSA in Japan
Summary
To the Editor: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which carries genes for Panton-Valentine leukocidin (PVL), has become a major concern worldwide [1,2,3]. All cases of PVL-positive CA-MRSA infections officially reported in Japan were caused by strains belonging to ST30 [9] All these strains can be classified into 2 types on the basis of spa type (Table), for example, ST30:spa19:SCCmecIVc. All these strains can be classified into 2 types on the basis of spa type (Table), for example, ST30:spa19:SCCmecIVc This type includes strain NN1, isolated from an 11-month-old patient with bullous impetigo [8]; strain NN12, isolated from a 17-year-old patient with cutaneous abscess/osteomyelitis [8]; strain NN31, isolated from an 18-year-old patient with pelvic abscesses [9]; and strain EB00449, isolated from a 27-year-old patient with cutaneous abscesses [9]. Characteristics of PVL-positive MRSA strains reported in Japan since 2000*
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