Abstract
The forte of nuclear medicine is quantitation: it is the numbers, not the images, that count. Radioisotopic techniques are particularly well suited to the estimation of renal function. Glomerular filtration rate (GFR) can be easily estimated from the plasma clearance of solutes such as 51Cr-EDTA that are rapidly distributed in the extracellular fluid (ECF) and cleared by glomerular filtration. Single exponential analysis carries a systematic error (the Chantler “fudge factor”), but is very reproducible in the same individual. Individual kidney GFR (IKGFR), estimated from the absolute uptake of 99Tcm-DTPA, correlates very well with 51Cr-EDTA plasma clearance GFR in children with a solitary kidney. Estimates of renal function must be related to body size. Traditionally, body surface area (SA) has been used, but there is a case for ECF volume instead.
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