Pediatric Multisystem Inflammatory Syndrome Physiopathology and Covid-19

Abstract

There are now more than 4 million confirmed cases of COVID-19, and more 285,000 deaths. The risk of severe disease and death has been highest in older people, and associated with age and one or more of the risk factors such as noncommunicable diseases (NCDs): hypertension, cardiovascular diseases, chronic lung diseases,kidney chronic disease, cancer and immunocompromised patients,or those exposed to high viral loads [1,2]. Children has more ACE2/ACE 2 receptors in mouth and nose and the elderly in the lungs, but there are also receptors in the kidney, endothelial cells and epithelial cells in the gastrointestinal tract,may be thatis why the symptomsdescribed in children were generally milder in children compared toadults, but some children do require hospitalization and intensive care [3], and now in Europe and USA there has been described a new syndrome that appears till 4 weeks after infection with SARSCoV-2-The Pediatric Multisystem Inflammatory Syndrome.