Pediatric In-Hospital Cardiac Arrest International Registry (PACHIN): protocol for a prospective international multicenter register of cardiac arrest in children

Jimena Del Castillo,Débora Sanz ,Laura Herrera ,Jesús López‐Herce ,Grupo De Estudio De Parada Cardiaca Intrahospitalaria En La Infancia

doi:10.1186/s12872-021-02173-5

Abstract

Background and aimsCardiac arrest (CA) in children is a major public health problem. Thanks to advances in cardiopulmonary resuscitation (CPR) guidelines and teaching skills, results in children have improved. However, pediatric CA has a very high mortality. In the treatment of in-hospital CA there are still multiple controversies. The objective of this study is to develop a multicenter and international registry of in-hospital pediatric cardiac arrest including the diversity of management in different clinical and social contexts. Participation in this register will enable the evaluation of the diagnosis of CA, CPR and post-resuscitation care and its influence in survival and neurological prognosis.MethodsAn intrahospital CA data recording protocol has been designed following the Utstein model. Database is hosted according to European legislation regarding patient data protection. It is drafted in English and Spanish. Invitation to participate has been sent to Spanish, European and Latinamerican hospitals. Variables included, asses hospital characteristics, the resuscitation team, patient’s demographics and background, CPR, post-resuscitation care, mortality, survival and long-term evolution. Survival at hospital discharge will be evaluated as a primary outcome and survival with good neurological status as a secondary outcome, analyzing the different factors involved in them. The study design is prospective, observational registry of a cohort of pediatric CA.ConclusionsThis study represents the development of a registry of in-hospital CA in childhood. Its development will provide access to CPR data in different hospital settings and will allow the analysis of current controversies in the treatment of pediatric CA and post-resuscitation care. The results may contribute to the development of further international recommendations.Trial register: ClinicalTrials.gov Identifier: NCT04675918. Registered 19 December 2020 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/record/NCT04675918?cond=pediatric+cardiac+arrest&draw=2&rank=10

Highlights

IntroductionThanks to advances in car‐ diopulmonary resuscitation (CPR) guidelines and teaching skills, results in children have improved
Background and aimsCardiac arrest (CA) in children is a major public health problem
This study represents the development of a registry of in-hospital CA in childhood

Summary

Introduction

Thanks to advances in car‐ diopulmonary resuscitation (CPR) guidelines and teaching skills, results in children have improved. The objective of this study is to develop a multicenter and international registry of in-hospital pediatric cardiac arrest including the diversity of management in different clinical and social contexts. Participation in this register will enable the evalua‐ tion of the diagnosis of CA, CPR and post-resuscitation care and its influence in survival and neurological prognosis. Pediatric in-hospital cardiac arrest (IHCA) is a rare event with possible devastating consequences It is considered a major public healthcare problem. In the treatment of in-hospital CA there are still multiple controversies and gaps of knowledge

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