Abstract
Pediatric cancers, like all the diseases arising in children, bring together numerous very rare diseases which make each of them “orphan diseases”. However, cancer remains the first disease-related cause of death in most of the middle-high income countries with an incidence of approximately 1 in 7000 children younger than 19 years of age. The selected case reports offer a great panel of diagnosis and/or treatment challenges, which, I hope, could help clinicians in their daily practice and give the motivation to younger practitioners to continue and develop clinical research.
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