Abstract
Extensive biological study has been made of the gonadotropic substance, prolan, which occurs in the urine of pregnant women. Unlike the gonadotropic hormone occurring in the anterior hypophysis itself, prolan even when concentrated, is sharply limited1 in its capacity to cause development of the ovaries in immature rats. When combined with a special synergic principle of the anterior hypophysis,2, 3 a marked augmentation of the ovary weights occurs. The gonadotropic effects are then fully equal to those produced by the most potent extracts of the gland itself.In the study of the synergism phenomenon with prolan-like substances from sources other than pregnancy, the urines of several types of malignancy were investigated. Among these cases was an individual suffering from embryonal carcinoma of the testis with generalized metastases. Ferguson4 has shown the remarkably high prolan unitage in the urine of such cases.The urine in question had an extraordinarily high unitage (50,000 mouse units per liter). In ...
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