PECULIARITIES OF THE COMBINED COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND TYPE 2 DIABETES MELLITUS

Abstract

The aim of the research was to study the features of chronic obstructive pulmonarydisease (COPD) with concomitant diabetes mellitus (DM) type 2 by analyzing clinicaldata, external respiratory function (FAD), bioimpedance analysis, exercise tolerance,quality of life of patients and integrated index BODE.Material and methods. 102 patients with COPD and concomitant type 2 diabetes,divided into 2 groups: 53 patients with COPD (first group) and 49 patients with COPDand concomitant type 2 diabetes were examined. In addition to that COPD assessmenttest (CAT test), a 6-minute walk test were performed. The BODE integrated index wasused to assess the COPD severity of and prognosis. According to spirometry, the studyincluded COPD patients with a FEV1 / FJEL ratio less than 0.7 and with II, III and IVdegrees of bronchial obstruction according to the spirometric classification GOLD. Toassess the body composition the method of bioimpedance analysis (portable device BC-601 (TANITA, Japan) was used.Results. In the study of COPD clinical features with concomitant type 2 diabetes, therelationship between exacerbation frequency and the level of diabetes compensation (p<0.05) was revealed. The duration of inpatient treatment of patients with COPD withconcomitant type 2 diabetes was higher than in patients with COPD (p <0.05). It hasbeen also found that the main spirometric parameters and exercise tolerance in patientswith COPD with concomitant type 2 diabetes were significantly lower than in the groupof COPD patients, and muscle and bone mass, percentage of fat mass, visceral fat andmetabolic age were significantly higher than in the group of COPD patients. Whenassessing the quality of life of patients with COPD by CAT test, there was no significantdifference between groups of patients.Conclusions. In patients with COPD in the presence of concomitant type 2 diabetesthere are more frequent and prolonged exacerbations with severe clinical symptoms, aswell as lower basic spirometric parameters, tolerance to exercise (according to the testwith 6-minute walk) with significantly higher bioimpedance analysis (BMI, % fat mass,visceral fat, bone, muscle mass and metabolic age).Key words: chronic obstructive pulmonary disease, diabetes mellitus, spirometry,bioimpedance analysis, exercise tolerance.