Abstract
Nowadays, coronary heart disease and non-alchoholic fatty liver disease are significant problems in Ukraine and world. Functional liver disorders potentiate the development and progression of CHD. The initiation process of atherosclerosis is a chronic systemic inflammation of low intensity. This view on atherosclerosis development has been forming during the past two decades. The aim of the research was to study the features/characteristics of systemic inflammation of low intensity in patients with coronary heart disease in combination with non-alcoholic fatty liver disease. The research involved 135 people with CHD: stable angina, I-II functional class, 0-I heart failure in combination with non-alcoholic fatty liver disease and 30 healthy individuals. We examined patients in terms of blood levels of cytokines -TNFα and IL-10, the content of the acute phase reactant and the coagulation factor, the marker of endothelial dysfunction is the amount of circulating endothelial microparticles (CEM) CD32+ CD40+ and the expression level of IkBα gene NF-kB in mononuclear peripheral blood. We studied the level of expression of the mRNA gene of IkBα in mononuclear cells, which reflects the level of transcriptional activity of NF-kB in patients with stable coronary artery disease and CHD in combination with NAFLD showed a significant increase in the expression of the mRNA gene of IkBα by 88.5% compared to patients with stable stable coronary heart disease. The analysis of the functional state of the endothelium with help of CEM CD32+ CD40+ has shown the presence of endothelial dysfunction in the groups of patients with CHD and CHD in combination with of NAFLD. Comparison of the indicators of systemic inflammation of low intensity and marker of endothelial dysfunction in patients with CHD in combination with NAFLD revealed a significant increase of TNFα, acute phase reactant and coagulation fibrinogen factor and expression of the mRNA IkBα gene in patients with comorbidity, indicating an increase the level of systemic inflammation of low intensity in patients with CHD in combination with NAFLD as compared with the group of patients with CHD.
Highlights
IntroductionThe initiation process of atherosclerosis is a chronic systemic inflammation of low intensity
This work is a part of planned research project of the Department of Propaedeutics of Internal Medicine with Medical Attendance, General Practice (Family Medicine), UMSA entitled: “Features of the course and prognosis of metabolic syndrome taking into account the genetic, age, gender aspects of patients, the availability of various components in metabolic syndrome and specific accompanying pathology and the ways of correction of detected disorders”
Numerous studies prove the close connection between systemic inflammation of low intensity, oxidative stress and atherosclerotic lesions of the vascular wall [12]
Summary
The initiation process of atherosclerosis is a chronic systemic inflammation of low intensity. This view on the development of atherosclerosis began active development last two decades [9,10]. Numerous studies prove the close connection between systemic inflammation of low intensity, oxidative stress and atherosclerotic lesions of the vascular wall [12]. Scientific achievements of recent years recognize endothelial dysfunction as one of the most important links in the pathogenesis of atherosclerosis [1,2,17]. Disturbance of the endothelium properties in result of damaging of the cell membrane by free radicals, modified LDL, antigenic complexes, monocytes-macrophages, cytokines, leads to activation of endothelial cells with subsequent apoptosis and formation of a stable imbalance of all endothelialdependent functions [18]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
