Abstract
Abstract. The aim of study was to investigate peculiarities of specific immune responses in vaccinated and unvaccinated measles convalescents. Twelve infants with natural measles infection at 5–7th day after onset of rash (Group 1), 14 adults with natural measles infection at 5–7th day (Group 2), 13 adults with measles at 12–15th day after onset of rash (Group 3), and 15 measles patients previously vaccinated against measles (Group 4) were examined. Fifteen healthy adults had twodose measles vaccination at 1 year and 6 years old (Group 5), and 17 healthy adults had measles many years ago (Group 6) were included in the study as a control groups. Specific IgM, IgA, IgG antibodies in serum, and their subclasses and avidity were tested by ELISA. High level of specific IgM and IgA-antibodies, and increasing of low-avidity IgG-antibodies, predominantly IgG3 subclass were typical for the humoral immune response in unvaccinated patients. On the contrary, lower level of IgM and the highest level of specific IgA and high-avidity IgG, predominantly IgG1 subclass characterized the group of previously vaccinated measles patients. The humoral immune response in vaccinated volunteers was characterized by lower level of specific IgA, IgG and avidity than in adults had measles in their childhood (group 6). The laboratory plays a critical role in case classification when rash and fever develop in persons who have possibly been exposed to measles. Waning of measles antibody, however, does not necessarily equate to waning immunity, because B-memory cells responses can increase of the antibody synthesis.
Highlights
Twelve infants with natural measles infection at 5–7th day after onset of rash (Group 1), 14 adults with natural measles infection at 5–7th day (Group 2), 13 adults with measles at 12–15th day after onset of rash (Group 3), and 15 measles patients previously vaccinated against measles (Group 4) were examined
Lower level of IgM and the highest level of specific IgA and high-avidity IgG, predominantly IgG1 subclass characterized the group of previously vaccinated measles patients
The humoral immune response in vaccinated volunteers was characterized by lower level of specific IgA, IgG and avidity than in adults had measles in their childhood
Summary
ФБУН Московский НИИ эпидемиологии и микробиологии им. Г.Н. Целью работы было исследование особенностей специфического гуморального иммунного ответа на дикий вирус кори ранее привитых и не привитых против этой инфекции. Пятнадцать здоровых взрослых, дважды привитых в детстве против кори (группа 5) и 17 здоровых взрослых, перенесших в анамнезе корь (группа 6), были выбраны в качестве контрольных групп. В группах не привитых пациентов выявлен высокий уровень специфических IgMи IgA-антител, нарастание количества низкоавидных специфических IgG, преимущественно IgG3-субкласса. Для ранее привитых больных корью было типично небольшое количество IgM и высочайший уровень специфических IgA и высокоавидных IgG, преимущественно IgG1-субкласса. Гуморальный иммунный ответ у вакцинированных в детстве добровольцев характеризовался более низким уровнем специфических IgA, IgG и их авидности, чем у переболевших корью в детстве из группы 6. Габричевского Роспотребнадзора, Москва; Мамаева Т.А., к.м.н., ведущий научный сотрудник лаборатории иммунохимии ФБУН МНИИЭМ им.
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