Abstract
The prevalence of H.pylori virulence genes ( iceA, cagA, babA2, vacA) as well as the distribution of the IL-1 genes was studied in patients with H.pylori -associated gastric and duodenal ulcer disease. VacA s1/m2 iceA1 cagA + и vacA s1/m2 iceA1 cagA + babA2 genotypes of H. pylori were shown to be prevalent in the clinic isolates. Four patients were found to be infected with Ureaplasma urealyticum . The combination of the IL‑1B ‑511 * Т / IL‑1B +3954 * C / IL-1RN * 2 alleles was shown to be prevalent among the patients with gastric and duodenal ulcer disease. The correlation between the H. pylori genotypes, the IL-1 genes and the peculiarities of ulcer disease was not found.
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