Abstract
The changes in a shape, a structure and mechanical properties of erythrocyte membrane after the treatment of whole human blood with peroxynitrite were studied by the methods of light, electron scanning and atomic force microscopy. The primary mechanisms of the changes in erythrocyte shape (acanthocytosis and spherocytosis) at the action of reactive nitrogen species state to be lipid phase separation as a result of lipid peroxidation and spectrin aggregation.
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