Abstract
To assess and substantiate the structural and metabolic mechanisms underlying the formation of intoxication, we studied the state of the pool of free plasma amino acids under the influence of sodium fluoride in the context of chronic fluoride intoxication in white rats of the Wistar population, which were orally administered sodium fluoride for 1.5 months at a dose of 20 mg / kg of body mass. Evaluation of the state of protein metabolism was conducted according to the spectrum of free plasma amino acids by ion exchange chromatography on ionites. Our studies have shown a decrease in plasma concentrations of free amino acids such as alanine, a-aminobutyric acid, threonine, serine, proline, valine, lysine, and an increase in taurine, aspartic, glutamic acid, glycine, and cysteine. The dynamics of cystine, methionine, leucine, isoleucine, cystianine, tyrosine, phenylalanine, ornithine, histidine, arginine, ammonia were not disrupted as compared with the control observation group. The decrease in the protein synthesizing function and the prevalence of catabolic processes over anabolic processes was also confirmed by the inhibition of the incorporation processes of 3H-thymidine, 3H-uridine and 14C-leucine in hepatocytes and splenocytes, which once again indicates a slowdown of synthetic processes.
Highlights
The key role of amino acids in the processes of interstitial metabolism is well known
The state of the pool of free plasma amino acids was studied on white rats of the Wistar population, which were orally administered a solution of sodium fluoride for 1.5 months, in a dose of 20 mg / kg
The study of the pool of free plasma amino acids under the condition of chronic fluoride intoxication showed significant differences in the amino acid spectrum in the control and experimental groups of white rats. This primarily indicates that the intake of sodium fluoride at a dose of 20 mg / kg of animal mass leads to profound structural and metabolic shifts in the body during the development of fluoride intoxication
Summary
The key role of amino acids in the processes of interstitial metabolism is well known. The development of many pathological conditions is inconceivable without structural and metabolic disorders associated with protein or amino acid. Amino acids can serve as a source of energy, mainly due to the oxidation of their carbon skeleton. In the body, they form a pool, the value of which is constant under physiological conditions. They form a pool, the value of which is constant under physiological conditions It corresponds to the difference between the intake of amino acids from the outside or sometimes from endogenous sources, and the consumption of amino acids, which serve as substrates in anabolic and catabolic processes. The rate of decomposition and synthesis of individual proteins is different for different tissues of the same organism
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