Peculiarities of lymphotropic antibioticotherapy in a combat trauma of abdominal organs (clinic-experimental investigation)

Abstract

Objective. Studying of impact of regional lymphotropic antibacterial therapy on various abdominal organs and application of the results in a combat abdominal trauma.
 Materials and methods. In the experiment accumulation of ceftriaxone in various abdominal organs was investigated, and detected by dimensions of the development zone delay in laboratory culture of E. coli in 1 – 2 h regional lymphotropic introduction of the preparation in a daily dose. Laboratory animals (rabbits) were withdrawn from the experiment, using overdosing of ketamine. After obtaining of specimen from certain organs, of them homogenate was processed and it was introduced into agar-agar, on which E. coli was cultivated. Separately, pure antibiotic (control) was introduced into the bacterial development zone as well. In a day the dimensions of the development zone delay in a test-culture was calculated, in accordance to which the level of accumulation of antibiotic was revealed.
 Results. The biggest dimensions of the development zone delay of E.coli were registered after antibiotic introduction into paravertebral and iliac zones, what have witnessed its maximal accumulation, accordingly, in gastric and pancreatic gland, the small bowel, coecum, sigmoid colon and the small omentum, and peritoneal specimen. After intramuscular injection of the antibiotic the dimensions of the development zone delay of E.coli have appeared minimal, witnessing practically absent accumulation of the preparation in specimen of the organs investigated.
 Conclusion. Accumulation of ceftriaxone in various organs in different inhibitory dose, concerning development of E. coli, witnesses the necessity to use the regional paths of lymphotropic introduction of antibiotic into certain abdominal zone of purulent-inflammatory process. Intramuscular introduction of antibiotic is not expedient in such inflammatory processes.