Peculiarities of enterovirus infection in children in Lviv region in 2015 year

Abstract

Introduction. Enterovirus diseases occupy the one of the main places among the viral infections in Ukraine and beyond it. More than half of all diseases with tremens in children are caused by enteroviruses.Grounding of research. The significant prevalence of enteroviruses, their high durability in the external environment, absence of the specific prophylaxis and also the cases of virus spread after the end of disease are the cause of both sporadic and mass diseases, result in the growth of their number caused by the wide spectrum of enteroviruses (Kockaki ЕСНО viruses) and development of the different clinical forms – from asymptomatic and catarrhal ones to the forms with the heavy injuries of the nervous system and internal organs. The most patients are children.Aim. To analyze the epidemiological and clinical features of enterovirus infection in children of the different age groups according to the results of retrospective studies.Materials and methods. There were analyzed 305 medical records of stationary sick children 1 month – 18 years old (mean age– 64,31 month (95% EI:51,78 – 60,75), who were treated in MI LRC “LRICH”from 01.01.2015to 31.12.2015 for enterovirus infection (EI), reports of sanitary-epidemiological institution of the Lviv region for this period.Results of research. During the year on the stationary treatment were patients with the different clinic forms of EI. There was observed the distinct summer-autumn seasonality of EI with the reliably higher morbidity index in August– 26 persons (38,23±5,8%), September – 16 (38,09±12,1%), October – 43 (78,18±5,5%). Patients without the injury of brain cortex dominated - 195 persons (63,93±2,7%), serous meningitis developed in 110 children (36,07±2,7%). It was detected that in 19,09% of cases the serous meningitis was caused by ЕСНО-30 and Kokcaki- V. I. viruses. ЕІ was registered more frequently in children of 1-4 years old (112 patients 36,72±2,7%), among which prevailed patients with herpangina - 96 patients (85,71±3,3%). There was established the negative correlation between the cases of herpangina and the age of patients (r= - 0,57 (р<0,05). Between the frequency of the serous meningitis and age of child – the reliable positive correlation (r=0,602, p=0,0001). Conclusions:1. Among the patients hospitalized at LRICH during 2015 the most frequent cases of EI were diagnosed in children of 1-4 years old, most patients had herpangina 96 (85,71±3,3%), among them in 10 (8,933,1%) herpangina was combined with exanthema, meningitis was detected in 9 patients (8,0±2,5%).2. The number of cases of serous meningitis grows with the age of child that is proved with the reliable positive correlation (r=0,602, p=0,0001).3. There was established the distinct summer-autumn seasonality of both EI (the most patients were detected in August - 68 (22,29±2,3%), October - 55 (18,03±2,2%), September - 42 (13,77±2,0%) and serous meningitis (in August - 26 (23,63±4,0%), in September - 16 (14,54±3,4%), in October - 43 (39 03±4,6%).4. The spinal puncture, general and virological studies of CSF in the season of higher EI morbidity level is the necessary component of diagnostics of the serous meningitis even at the absence of meningeal symptoms