Abstract
The aim: of the study was to elucidate the changes to nitric oxide activity in the blood during adrenaline-induced myocardial injury under immobilization stress and to establish the corrective effect of L-arginine.
 Methods: determination of free arginine was conducted by the method of Aleinikova T.L., total nitric oxide products in the blood by the method of Schmidt H.H., the total activity of nitric oxide synthase by the method of Sumbaiev V.V.. Immobilization stress was reproduced by the method of Horizontov P.D. Adrenaline-induced myocardial injury was reproduced by the method of Markova O.O. L-arginine was injected based on scientific data by Kiryanova N.A.
 Results. Studies have shown that on days 1 and 3 with adrenaline-induced myocardial injury under immobilization stress there was an increase in nitric oxide products in the blood, respectively, according to control. The use of L-arginine on the 5th day, led to a decrease in levels of NO products in the blood by less than, lower against the group of animals with MI and IS, to treatment.
 Conclusions. Thus, biochemical studies of NO system in the dynamics of IS and MI showed an increase in food content and total synthase activity of NO on the background of reduced levels of L-arginine, which were detected at all stages of the study and especially expressed on the 1st day before treatment. The use of the drug L-arginine, made it possible to identify its corrective effect on impaired metabolic processes in MI and IS
Highlights
Arginine metabolism is depend of the activity of nitric oxide syntetase and arginase enzymes
The conducted biochemical study of the total activity of nitric oxide synthases showed an increase in their activity in the blood by 1, 3 and 5 days, respectively, by 204.3±4.2 % (p
The level of free arginine in the blood with adrenaline-induced myocardial injury under conditions of immobilization stress on the 1st, 3rd and 5th days of the experiment decreased by 80.7±1.6 %, (p
Summary
Arginine metabolism is depend of the activity of nitric oxide syntetase and arginase enzymes. Nitric oxide syntetase oxidases arginine to citrulline and NO, and arginase hydrolyzes arginine into ornithine and urea [1]. Comorbid pathology is observed quite often in the clinic of internal diseases. Concomitant pathology complicates the course of the underlying disease, worsening the survival prognosis of patients. The stress system is a regulatory system, which is represented by three constituents: nervous, endocrine and immune, the action of which is aimed at maintaining homeostasis [2]. Catecholamines released in response to activation of the sympatho-adrenal system, together with the autonomic nervous system, have a regulatory effect on the cardiovascular and immune systems, lungs, liver and skeletal muscles [4, 5]
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