Peculiarities of climacteric syndrome in women with bronchial asthma, developed in the perimenopausal period, correction of these disorders

Abstract

The aim to study the peculiarities of climacteric syndrome (CS) in women with bronchial asthma (BA) which first-time onset in perimenopausal (peri-MP) period, effectiveness of hormone replacement therapy (HRT). Methods: 18 women with BA, developed in the peri-MP period, aged from 46 to 54 years (mean 50,9 ± 0,6) were assessed. Physical examination, menopausal index, levels of follicle-stimulating (FSG), luteinizing hormones (LG), estradiole and progesterone were performed. As a HRT estradiole valerate 2 mg and cyproterone acetate 1 mg were used. Results: CS was detected in 15 (88,3%) pts, mild CS - in 3 (20 %) pts, moderate CS – in 7 (46,7 %) pts, severe CS – in 5 (33,3 %) pts. Predominant symptoms were hot flushes – 13 (86,7 %) pts, palpitations – 9 (60 %), irritability – 8 (53,3 %). Decrease levels of estradiole and progesterone, increase concentration of FSH, LH were found. For correction of menopausal disorders a gr. of 8 pts with moderate and severe CS was formed. All women were not obese, mean BMI – 26,8±0,6 kg/m 2 . The using of HRT for 12 months was associated with decreasing of CS severity (p=0,0001), the most effective was reduction of neurovegetative symptoms. Also, the pts reported a decrease in asthma exacerbations (p=0,024) and the need for short-acting β 2 -agonists. Decrease in serum levels of FSH (p=0,018), LH (p=0,014) and increase in estradiole (p=0,015), progesterone (p=0,023) were found. Conclusion: Most patients with asthma which first-time onset in peri-MP period had a climacteric syndrome, which impairs the patients quality of life. HRT effectively reduces menopausal disorders, had a positive influence on asthma.