PECULIARITIES OF CHOLELITHIASIS CLINICAL COURSE IN PATIENTS WITH TYPE 2 DIABETES

Abstract

Diabetes mellitus (DM) is characterized by multi-organ and systematic damage. In 70% of cases diabetes is accompanied by digestive system diseases. Rather often diabetes is associated with a wide range of diseases of the hepatobiliary system, which are able to impede its progress and worsen the prognosis. Diabetes is also considered as a factor that triggers the development of gallstone disease (GSD).The purpose – to analyze the peculiarities of the pathology of the gall bladder in patients with type 2 diabetes.Material and methods. A comprehensive survey of 170 patients with type 2 diabetes (113 women and 57 men, average age constituted 60,8±0,9 years) was carried out. Verification of diagnosis of diabetes was based on the determination of carbohydrate balance and level of glycated hemoglobin. The diagnosis of chronic cholecystitis was verified on the basis of clinical data, characteristic changes of the gallbladder wall according sonography (wall thickness greater than 3 mm, compression and deformation of the wall). The diagnosis of cholelithiasis was made at the presence of concrements in the lumen of the gall bladder according to ultrasound.Results and conclusions. Reliable predominance was ascertained among patients with comorbidity females. It has been found out that GSS has minimal non-specific clinical course more often in patients with GSD type 2 diabetes. The characteristic laboratory changes of blood biochemical parameters were not found. Reliably method of diagnosis of pathological changes in the gall bladder (concrements) is ultrasound investigation. However, it is impossible to diagnose the earliest changes in the gallbladder, using this method.