Peculiarities in clinical and pathomorphological manifestations of osteoarthrosis of their lower extremities in patients with spondyloepiphyseal dysplasia

Abstract

The study involved 133 patients with stages 2–4 of osteoarthrosis of knee and hip joints, which developed against a background of spondyloepiphyseal dysplasia. It was revealed that changes in the locomotor system and veins of the lower extremities were the basic clinical manifestations of the syndrome of connective tissue dysplasia. Forty-five patients, who underwent total arthroplasty of their hip and knee joints, had densitometry, thermography and an immunological blood examination before the operation; after the surgical intervention, the regenerative potential of marrow stromal stem cells in the epiphyses of the femoral and tibial bones was studied by cloning the above cells in vitro and the articular cartilage was histologically examined. The revealed changes, including a threat of a decreased potential of the osseous tissue remodelling, give grounds to extend indications for arthroplasty in the above category of patients.