Abstract
5-Benzoylethyl barbituric acid derivatives 2a-c were prepared as useful precursors for the synthesis of pyrimidine fused heterocycles. Their behaviour as 1,5-diketocompounds towards aniline derivatives afforded the pyrimidoquinoline derivatives 6a-e. On the other hand, fusion of o -substituted anilines with 1,3-dimethyl barbituric acid derivatives 8a,b gave the corresponding benzazoles 10a-e. Furthermore, the reaction of 1,3-dimethyl barbituric acid ( 1) with catechol/K 3|Fe(CN) 6| or β-ketoester ( 19)/SiCl 4 gave the benzofuro adduct 13a and the diphenylphenyl barbituric acid derivative 18, respectively.
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