Abstract
In this work, synthesis and swelling behavior of a superabsorbent hydrogel based on Pectin (Pc) and polyacrylonitrile (PAN) were investigated. A mechanism for hydrogel formation was proposed and the structure of the product was es-tablished using FTIR spectroscopy. The Pc-poly (sodium acrylate-co-acrylamide) hydrogel exhibited a pH-responsive swelling-deswelling behavior at pH’s 2 and 8. This on-off switching behavior provides the hydrogel with the potential to control delivery of bioactive agents. Release profiles of ibuprofen (IBU), a poor water-soluble drug, from the hydro-gels were studied under both simulated gastric and intestinal pH conditions.
Highlights
Pectin is a naturally occurring biopolymer that is finding increasing applications in the pharmaceutical and biotechnology industry
Synthesis and swelling behavior of a superabsorbent hydrogel based on Pectin (Pc) and polyacrylonitrile (PAN) were investigated
Crosslinked polymers from Pectin can form hydrogels that are able to absorb and retain hundreds of times their weight of water and are known as superabsorbents [1]. The properties of these hydrogels have attracted the attention of many researchers and technologists and have found wide-spread applications in many fields, such as drug delivery systems, agriculture, separation processes [2,3,4,5]
Summary
Pectin is a naturally occurring biopolymer that is finding increasing applications in the pharmaceutical and biotechnology industry. Crosslinked polymers from Pectin can form hydrogels that are able to absorb and retain hundreds of times their weight of water and are known as superabsorbents [1]. The properties of these hydrogels have attracted the attention of many researchers and technologists and have found wide-spread applications in many fields, such as drug delivery systems, agriculture, separation processes [2,3,4,5]. This work deals with the development of new biodegradable hydrogels developed by the polymerization of AN and some formulations with sodium hydroxide as crosslinker, in the presence of Pectin
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