Abstract
Breast and prostate cancers are the most prevalent cancers among women and men in the United States. Pectin is a heteropolysaccharide found mainly in citrus fruits. In the present study, we evaluated the effect of pectin on highly invasive breast [MDA‐MB‐231] and prostate [PC3] cancer cells. We have found that pectin significantly reduced the migration of these cells, however, had no effect on proliferation. Interestingly, when pectin was combined with ProstaCaid & BreastDefend, breast and prostate dietary supplements respectively, it markedly further enhanced inhibition of invasive behavior of breast and prostate cancer cells. These effects were mediated through the down‐regulation of urokinase plasminogen activator (uPA) secretion. Further microarray analysis demonstrated that this treatment affected expression of cell‐cycle regulatory genes e.g. cyclinA2, CDC28, MCM2, TPD1, PCNA and CDKN1A which was confirmed by Western blot analysis. Our data suggests potential use of pectin with ProstaCaid or BreastDefend for the prevention and treatment of breast and prostate cancers, respectively.Grant Funding Source: Unknown
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