Abstract
Constipation is an area of concern in people’s health. Consequently, health care practitioners recommend lifestyle changes including increasing fiber intake and exercise. This study examined the effect of pea hull fiber (PHF) on loperamide-induced constipation in rats. The rats were fed either a vehicle diet or a diet enriched with PHF. The groups were divided into either a saline or loperamide injection to induce sub-acute constipation. Fecal Pellet Output (FPO) was measured for 3 days. In the saline-treated rats, PHF increased wet and dry fecal weights on day 1 and 2, and increased FPO on day 2 compared to the saline-treated rats on the vehicle diet. In the loperamide model, PHF increased FPO, had higher wet and dry fecal weights on day 1 compared to the loperamide-treated vehicle diet rats. Addition of PHF into the diet may help improve intestinal transit in a loperamide-induced constipation rat model.
Highlights
For many people, bowel irregularity is an area of great concern in their health [1]
This study examined the effect of pea hull fiber (PHF) on loperamide-induced constipation in rats
Given the beneficial clinical effects reported with oat hull fiber and chronic constipation, coupled with the rat study demonstrating improved transit time with pea hull fiber (PHF) we hypothesized that addition of PHF in a loperamide-induced constipation rat model [13] [14] would help improve bowel function
Summary
Bowel irregularity is an area of great concern in their health [1]. Constipation is clinically defined as infrequent and difficult defecation (
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