Abstract
Photodynamic therapy (PDT) for malignant tumors is performed increasingly throughout the world. However, detailed information concerning the optimum power density, light dose and thermal effects are unknown. Therefore the authors investigated tumor response and tumor temperature during PDT using transplanted B-16 melanoma in mice. A thermister probe was fixed at a depth of 2mm from the tumor surface. At the site, the tumor temperature rose 8°C at 150mW/cm2, 13°C at 300mW/cm2, 21°C at 450mW/cm22, 28°C at 600mW/cm2 above the base line value. A tumor response study showed increased effects with increased power density. Mice receiving a high power density (450mW/cm2, 600mW/cm2) without photosensitizer indicated same result. The presence of thermal effects was suggested in the high power density group of PDT. The increased light dose showed improvement of results over the low power density group (150mW/cm2, 300mW/cm2).
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