PDT Brazil - Comparison of response according two clinical trials for basal cell carcinoma treatment with MAL-PDT: the beginning of PDT Brazil project

Abstract

There aremany studies to achieve the ideal irradiance anddelivered energy during the photodynamic therapy for nodular basal cell carcinoma (BCCn). The aim of this study was a comparison of two different clinical protocols: it was selected 200 patients with BCCn less than 1 cm of diameter. A cream containing 15% MAL (methyl aminolevulinate, PDTPharma, Brazil)was applied and after three hours the lesions were illuminated using the device LINCE® (MMOptics, Sao Carlos-SP, Brazil) developed by a Brazilian project with financial support of the Brazilian Development Bank (BNDES). A hundred lesions received the PDT treatment with an irradiance of 100 mW/cm2 for 17 minutes, (100 J/cm2). The other 100 BCC lesions received an irradiance of 125mW/cm2 for 20minutes, (150 J/cm2). Another treatment session was performed after one week. After 30 days, the lesions were evaluated and taken for a biopsy. The 30rd day biopsy showed 77% and 88% of complete response for the 100 J/cm2 and 150 J/cm2, respectively. The comparison of these two clinical protocols shows that the better response leads to the use of 150 J/cm2 delivered energy for BCCn treatment.