Abstract
This study reports microwave-assisted cyanide-free synthesis of aryl nitriles from aryl halides using palladium acetate/1,1-bis(diphenylphosphino)ferrocene as a new catalyst system. Reported protocol is a rapid, cyanide-free, single step reaction, wherein formamide acts as a solvent as well as a source of cyanide. The use of microwave increases the rate of reaction substantially and it was observed that aryl nitriles can be synthesised in 50 min of microwave irradiation compared to conventional thermal heating protocol which requires 48 h. This study reports microwave-assisted cyanide-free synthesis of aryl nitriles from aryl halides using palladium acetate/1,1-bis(diphenylphosphino)ferrocene, a new catalyst system. Reported protocol is rapid, cyanide-free, solvent-free single step reaction, wherein formamide acts as a solvent as well as a source of cyanide.
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