Abstract
A concise synthesis of Hagen's gland lactones 3– 6 by a chiron approach starting from d-mannose is described. Transformation of d-mannose to dihydroxy-vinylfuran 8 followed by Pd(II)Cl 2 mediated oxidative cyclisation to obtain the tetrahydrofurofuran diol 7 constituted the key reaction in the total synthesis of 3– 6.
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