Abstract
Introduction. Techniques that use growth factors to improve bone fragment consolidation and to treat the inflammatory and degenerative diseases of the musculoskeletal system have become very popular. Many researchers are actively searching for personification of this therapy and the reasons for delayed consolidation. The purpose of the study – to identify the biomarker for delayed bone consolidation.Materials and Methods. The study groups consisted of patients with high-energy tibia open fractures with normal (group 1) and with delayed (2nd group) consolidation of bone fragments. The enzymatic activity of platelet-derived growth factor (PDGF) in blood serum was studied after 7 days and in 1, 3 and 6 months after bone fragments reduction. Spectrophotometric technique (Specord-200) was used.Results. In patients with normal consolidation of bone fragments, the enzymatic activity of PDGF was statistically significantly higher in comparison with the group with delayed healing. At the same time, the highest activity was reported on day 7, and by third month it was becoming lower.Conclusion. Bone healing depends on PDGF enzymatic activity, besides significant differences on various stages of healing were observed. Further study the reasons for the PDGF enzymatic deficiency and its correction are of a great interest for reducing the timing of consolidation.
Highlights
Techniques that use growth factors to improve bone fragment consolidation and to treat the inflammatory and degenerative diseases of the musculoskeletal system have become very popular
Bone healing depends on platelet-derived growth factor (PDGF) enzymatic activity, besides significant differences on various stages of healing were observed
Further study the reasons for the PDGF enzymatic deficiency and its correction are of a great interest for reducing the timing of consolidation
Summary
Многими исследователями ведется активный поиск вариантов персонифицирования данной терапии и причин замедленной консолидации. Цель работы — выявление биохимического критерия замедленной консолидации. Объектом наблюдения были пациенты с высокоэнергетическими открытыми переломами костей голени с нормальной (1 группа) и с замедленной (2 группа) консолидацией костных отломков. Изучали ферментативную активность тромбоцитарного фактора роста (PDGF) в сыворотке крови через 7 дней, а также через 1, 3 и 6 мес. У пациентов с нормальной консолидацией костных отломков ферментативная активность PDGF была статистически значимо выше по сравнению с группой, в которой консолидация была замедлена. Костная регенерация зависит от ферментативной активности PDGF. Изучение причин ферментативной недостаточности PDGF и их коррекция имеют большое значение для сокращения сроков консолидации. Ключевые слова: консолидация перелома, костная регенерация, тимидинфосфорилаза, тромбоцитарный фактор роста, катаболизм нуклеотидов
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