Abstract
BackgroundPanic disorder is a complex disease of unclear etiology but with an apparent genetic component. PDE4B gene product is involved in many cell processes owing to its function-regulation of the level of a second messenger cAMP. PDE4B gene polymorphism has been shown to be associated with some mental disorders including panic disorder.AimsThe goal of our study was to evaluate the role of 3 SNPs in the PDE4B gene in the development of panic disorder.Methods94 patients diagnosed with panic disorder according to the DSM-IV criteria were enrolled in the study. The population control group included 192 subjects. Genotyping was carried out by real-time PCR with TaqMan probes.ResultsThe investigated substitutions are not associated with panic disorder in general and in female/male cohorts (p > 0.05). The analysis of complex genotypes demonstrated two protective complex genotypes (rs1040716:A, T + rs10454453:A + rs502958:A and rs1040716:A, T + rs502958:A) associated with panic disorder in general regardless of the patient's gender (p < 0.05). These genotypes did not correlate with the patient's sex.ConclusionsWe found two complex protective genotypes associated with panic disorder. This can be due to the fact that predisposition to the disease are associated with other genes, while PDE4B gene polymorphism reduces their effect.
Highlights
Changes in the PDE4 subtype B (PDE4B) gene expression contributes to the change in intracellular cyclic adenosine monophosphate (cAMP) concentrations, which correlates with various psychiatric disorders
We evaluated the role of 3 SNPs in the PDE4B gene in the development of panic disorder and found two protective complex genotypes associated with panic disorder
The only study that evaluated the association of SNPs in the PDE4B gene with panic disorder demonstrated the relationship between a rs10454453 substitution and Panic disorderPanic disorder (PD) development
Summary
Panic disorder (PD) is a disorder characterized by sudden and recurrent attacks of anxiety, fear of death, fear of becoming insane accompanied by physical symptoms (dizziness, excessive sweating, palpitations and chest pain, shivering, feeling of shortness of breath, nausea and abdominal pain, paresthesia and derealization). Despite short duration (several minutes) of attacks, panic disorder has a significant impact on the quality of life of patients. Anxiety and fear of having a panic attack start persisting and limiting the patients’ daily activities. Frequent panic attacks (more than 1 attack per week) cause the most significant impact on the patient’s adjustment. Evidence of direct inheritance of the disorder from generation to generation has been obtained (the disorder is observed in 15–17% of relatives of patients with PD; 85–90% concordance in monochorionic twins; heritability 48%) [1]. Molecular genetic basis of this polygenic disorder has not been well studied [2]
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