Pd‐Catalyzed β‐Selective C−H Arylation of Thiophenes with Triarylantimony Difluorides

Abstract

AbstractRegioselective C−H arylation using pentavalent organoantimony compounds as a new class of arylating reagents is described. The reaction of thiophenes with triarylantimony difluorides in the presence of 5 mol% of and 2 equiv. CuCl2 at 80 °C under aerobic conditions afforded the β‐arylated thiophene derivatives in moderate‐to‐high yields. The reaction is sensitive to the electronic nature of the triarylantimony difluorides – those bearing an electron‐donating group on the phenyl ring showed higher reactivity than those have an electron‐withdrawing group.