PDB82 THE REAL-WORLD OBSERVATIONAL PROSPECTIVE STUDY OF HEALTH OUTCOMES WITH DULAGLUTIDE AND LIRAGLUTIDE IN TYPE 2 DIABETES PATIENTS (TROPHIES): COUNTRY-SPECIFIC BASELINE CHARACTERISTICS

Abstract

The first injectable therapy usually recommended for type 2 diabetes (T2D) is a glucagon-like peptide-1 receptor agonist (GLP-1 RA). Although randomized clinical trials are the standard for efficacy and safety assessments, observational studies may help to better understand the GLP-1 RA use in clinical practice. This abstract presents the baseline characteristics of patients enrolled in participating countries (France, Germany, Italy) of TROPHIES study. TROPHIES is a 24-month, prospective, observational study in adult patients with T2D initiating their first injectable glucose-lowering treatment with dulaglutide or liraglutide. At baseline, we assessed demographics, T2D duration, HbA1c levels, reported HbA1c targets and pre-existing diabetes-related diagnoses. Analyses were descriptive in nature. To date, we have analyzed data from 2065 patients (France: 342 and 260; Germany: 365 and 363, Italy: 382 and 353 patients for dulaglutide or liraglutide, respectively). In patients initiating dulaglutide or liraglutide, mean age (years) was 57.4 and 58.8 in France, 57.9 and 56.8 in Germany and 61.2 and 62.5 in Italy, respectively. BMI (kg/m2) for patients in France was 33.1 (dulaglutide) and 33.7 (liraglutide), it was 35.7 (dulaglutide) and 36.2 (liraglutide) in Germany and 32.6 (dulaglutide) and 32.4 (liraglutide) in Italy. Mean baseline HbA1c levels were similar across all three countries and exceeded mean reported HbA1c targets. In patients initiating dulaglutide or liraglutide, macrovascular diabetes-related conditions were reported in 4.1% and 16.9% in France, 6.3% and 5.5% in Germany and 13.6% and 13.6% in Italy, respectively. In patients from all three countries, mean BMI reflected obesity. Baseline HbA1c levels exceeding the reported targets justifies treatment justification with a GLP-1 RA. Variations in patients’ baseline characteristics across countries may be due to country-specific clinical guidelines and reimbursement policies. Thus, this study provides insight into the profiles of patients being prescribed dulaglutide or liraglutide in these countries.