PDB7 - Prevalence and timing of comorbid Complications of Type 2 Diabetes In Large Cohort of Insurance Subscribers

Abstract

Type 2 Diabetes(T2D) has multiple comorbid complications. Early detection of T2D can delay and prevent these complications. We study the prevalence and timing of occurrence of complications of diabetes including cardiovascular, cerebrovascular, renal, and eye complications, for patients newly-diagnosed with T2D. We studied a cohort of 4.1million insurance beneficiaries of age≥18yrs with recorded claims between 2005 and 2013. Among them 26,778 patients were newly diagnosed with T2D, and had continuous enrollment for 3-years prior-to- and 1-year post-T2D diagnosis. We defined diabetes complications based on the diabetes complications severity index. We assessed number and percentages of patients with each complication, in total, and in relation to time of T2D diagnosis. Among 26,778 patients newly diagnosed with T2D, 13,538 had at least one complication during the observation period. Of these patients, 9,526(70%) had it before T2D diagnosis and 1,102(8%) had it within 6months after T2D diagnosis. A total of 10,143 patients had cardiovascular complications during observation period. Of these patients, 7,338(72%) had them before T2D diagnosis, and 720(7%) had them within 6months after T2D diagnosis. A total of 3,686 patients had cerebrovascular complications during observation period. Of these patients, 2,222(60%) had them before T2D diagnosis, and 294(8%) had them within 6months after T2D diagnosis. A total of 4,358 patients had renal complications during observation period. Of these, 2,215(50%) had them before T2D diagnosis, and 517(11%) had them within 6months after T2D diagnosis. A total of 2,286 patients had eye complications during study period. Of these patients, 928(40%) had them before T2D diagnosis, and 355(14%) had them within 6months after T2D diagnosis. In our cohort, conditions associated with long-term complications of diabetes were commonly diagnosed before or soon after T2D diagnosis date. Better approaches for early detection and treatment of T2D are needed, to prevent or delay its complications.