PD63-03 UTILITY OF BLUE LIGHT FLEXIBLE CYSTOSCOPY FOR BLADDER CANCER SURVEILLANCE AFTER INTRAVESICAL THERAPY

Abstract

You have accessJournal of UrologyBladder Cancer: Non-invasive III (PD63)1 Sep 2021PD63-03 UTILITY OF BLUE LIGHT FLEXIBLE CYSTOSCOPY FOR BLADDER CANCER SURVEILLANCE AFTER INTRAVESICAL THERAPY Sanam Ladi Seyedian, Xiaosong Meng, Sidney Roberts, Hamed Ahmadi, Jeffrey Howard, Iftach Chaplin, Aditya Bagrodia, Vitaly Margulis, Solomon Woldu, Yair Lotan, and Siamak Daneshmand Sanam Ladi SeyedianSanam Ladi Seyedian More articles by this author , Xiaosong MengXiaosong Meng More articles by this author , Sidney RobertsSidney Roberts More articles by this author , Hamed AhmadiHamed Ahmadi More articles by this author , Jeffrey HowardJeffrey Howard More articles by this author , Iftach ChaplinIftach Chaplin More articles by this author , Aditya BagrodiaAditya Bagrodia More articles by this author , Vitaly MargulisVitaly Margulis More articles by this author , Solomon WolduSolomon Woldu More articles by this author , Yair LotanYair Lotan More articles by this author , and Siamak DaneshmandSiamak Daneshmand More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002107.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Previous studies have demonstrated the benefit of blue light flexible cystoscopy (BLFC) in clinical practice though detection of additional cancers missed with white light cystoscopy (WLC) alone. However, the utility of BLFC for surveillance in patients receiving intravesical treatments has not been extensively studied. Identifying early recurrences in these patients can result in better stratification and possibly improved outcomes. Herein, we aim to evaluate the utility of BLFC for surveillance of bladder cancer post intravesical therapy. METHODS: Clinicopathologic information was collected from consecutive patients undergoing office-based BLFC who were enrolled in the Cysview registry between May 2018 and December 2020 at two high volume academic centers. Patients with last intravesical treatment >1 year were excluded. Data were stratified based on the time from last intravesical treatment. RESULTS: A total of 277 BLFC were performed in 136 patients (mean age 73 years). 85% were male, 61% had history of smoking and 30% had ³2 prior bladder cancer recurrences. 74% had high grade (HG) disease and the highest stage prior to BLFC was Ta, T1, carcinoma in situ (CIS), and Ta/T1+CIS in 40%, 34%, 17% and 9%, respectively.Intravesical Bacillus Calmette–Guérin (BCG) and intravesical chemotherapy were used in 83% and 17%, respectively. WLC and BLFC were both normal in 162 (58.5%) procedures. WLC or BLFC was abnormal in 40% of post BCG and 37% of post intravesical chemotherapy cystoscopies.A total of 52 office biopsy were taken, of which, 23/52 (44%) were malignant (Table 1). BLFC was abnormal in all positive biopsies, while only 3/23 had positive or atypical cytology. BLFC was 100% sensitive for detection of cancer in this cohort. WLC was normal and BLFC was abnormal in 23 (8%) procedures. Of these, 16/23 had office-based biopsy and cancer was detected in 9/16. BLFC had the highest false positive rate at <6 weeks post intravesical therapy. CONCLUSIONS: Office-based BLFC helps improve early detection of recurrence in cases with normal WLC. BLFC can help in surveillance of patients receiving intravesical therapy, improve performance of office-based biopsy and increase early detection of BCG unresponsive disease. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1138-e1139 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sanam Ladi Seyedian More articles by this author Xiaosong Meng More articles by this author Sidney Roberts More articles by this author Hamed Ahmadi More articles by this author Jeffrey Howard More articles by this author Iftach Chaplin More articles by this author Aditya Bagrodia More articles by this author Vitaly Margulis More articles by this author Solomon Woldu More articles by this author Yair Lotan More articles by this author Siamak Daneshmand More articles by this author Expand All Advertisement Loading ...