PD62-11 THERAPEUTIC EFFECT OF LIPOSOMAL DELIVERY OF HYDROGEN SULFIDE AND XENON ON ERECTILE FUNCTION AFTER CAVERNOUS NERVE INJURY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Basic Research & Pathophysiology (PD62)1 Sep 2021PD62-11 THERAPEUTIC EFFECT OF LIPOSOMAL DELIVERY OF HYDROGEN SULFIDE AND XENON ON ERECTILE FUNCTION AFTER CAVERNOUS NERVE INJURY Baibing Yang, Dustin Luse, Song Gao, Shaolin Huang, Yong-jian Geng, and Run Wang Baibing YangBaibing Yang More articles by this author , Dustin LuseDustin Luse More articles by this author , Song GaoSong Gao More articles by this author , Shaolin HuangShaolin Huang More articles by this author , Yong-jian GengYong-jian Geng More articles by this author , and Run WangRun Wang More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002099.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Erectile dysfunction (ED) is a neurovascular disorder mediated by dysfunction of the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway, and poor relaxation of corpus cavernosum smooth muscle. The two gaseous molecules, hydrogen sulfide (H2S) and xenon (Xe), have been shown to exert neurovascular protective effects in the setting of ischemic and traumatic injuries. Administration of H2S and Xe has been shown to reduce infarct sizes and improve function in animal models of cerebral ischemia–reperfusion injury. The current study tested the hypothesis that to a similar extent, H2S and Xe both can preserve erectile function after cavernous nerve injury. METHODS: A model of cavernous nerve injury ED was employed using bilateral cavernous nerve crush (BCNC) on adult male Sprague Dawley rats. The experimental and control groups were BCNC + saline, BCNC + H2S, BCNC + Xe treatment and a sham surgery control group. H2S treatment was used as positive control, which has been reported to improve erectile function through smooth muscle relaxation. H2S and Xe were packed in echogenic liposomes (ELIPs, liposome diameter ranged from 800 nm to several microns) respectively and injected through the rat tail vein (5mg ELIPs). Gas was released from ELIPs under ultrasound exposure at the root of penis. Intracavernosal pressure (ICP) and mean arterial pressure (MAP) were examined after ultrasound exposure and recorded for all groups. RESULTS: Rats injured by BCNC showed erectile dysfunction evidence by reduced ICP/MAP. Treatment with H2S and Xe blocked the BCNC adverse impact on erectile function by 1.83- and 1.75-fold increases respectively when compared with BCNC group. CONCLUSIONS: Liposomal delivery of H2S and Xe demonstrates potential as a novel therapy for ED after cavernous nerve injury. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1076-e1076 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Baibing Yang More articles by this author Dustin Luse More articles by this author Song Gao More articles by this author Shaolin Huang More articles by this author Yong-jian Geng More articles by this author Run Wang More articles by this author Expand All Advertisement Loading ...