PD59-02 COMPLICATIONS, RECOVERY, AND PATIENT-REPORTED QUALITY OF LIFE AFTER RADICAL CYSTECTOMY

Abstract

You have accessJournal of UrologyBladder Cancer: Invasive V (PD59)1 Sep 2021PD59-02 COMPLICATIONS, RECOVERY, AND PATIENT-REPORTED QUALITY OF LIFE AFTER RADICAL CYSTECTOMY Elizabeth Green, Ali Hajiran, Richard Reich, Logan Zemp, Aymet Aydin, Roger Li, Michael Poch, Wade Sexton, Alice Yu, and Scott Gilbert Elizabeth GreenElizabeth Green More articles by this author , Ali HajiranAli Hajiran More articles by this author , Richard ReichRichard Reich More articles by this author , Logan ZempLogan Zemp More articles by this author , Aymet AydinAymet Aydin More articles by this author , Roger LiRoger Li More articles by this author , Michael PochMichael Poch More articles by this author , Wade SextonWade Sexton More articles by this author , Alice YuAlice Yu More articles by this author , and Scott GilbertScott Gilbert More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002096.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Although cystectomy (Cx) is a morbid surgery, information regarding the effect difficult recovery has on patient-centered outcomes is lacking. Using validated patient-reported outcome (PRO) measures, we examined the relationship between perioperative complications, readmissions, diversion-related consequences and prospectively assessed PROs after Cx. METHODS: Patients undergoing Cx were enrolled in a prospective complication and PRO study from 2014 to 2016 and followed for 12 months. Participants completed the Medical Outcomes Study Short Form (SF-36), Bladder Cancer Index (BCI), Patient Health Questionnaire for Depression (PHQ-8) and Decision Regret Scale (DRS). Perioperative complications within 90 days of Cx were abstracted from medical records using Clavien-Dindo classification and urinary diversion adverse events (AEs) were prospectively assessed and graded 6 months after surgery using Common Terminology Criteria for Adverse Events (CTCAE) standards. The association between perioperative complications, readmissions, 6-month AEs, and PROs were analyzed using multivariable regression models. RESULTS: 113 patients enrolled in this study and had complication and AE data available for analysis. 47% experienced a low grade (LG) and 22% experienced a HG complication. 35% were readmitted. 82% experienced a LG and 19% experienced a HG AE within 6 months. Improved performance status was associated with decreased HG 90-day complications (p=0.009). SF-36 mental health composite score was significantly positively associated with readmission (p=0.04), but not complication or 6-month diversion AE. There was no significant relationship between the presence of a HG 90-day complication, readmission, or 6-month AE and SF-36 physical health (p=0.21, 0.26, and 0.20 respectively), urinary (0.46, 0.20, and 0.86), bowel (p=0.62, 0.63, and 0.85) or sexual domains of BCI (p=0.35, 0.28, and 0.30), PHQ-8 (p=0.89, 0.32, and 0.44), or DRS at 6 months (p=0.15, 0.97, 0.31, Table 1). CONCLUSIONS: HG 90-day complications, readmissions and 6-month AEs did not negatively affect PROs or QOL after recovery from Cx. These data suggest that perioperative complications and AEs do not lead to long-term QOL deficits. Source of Funding: Florida Biomedical Research Program, Bankhead-Coley Research Grant © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1051-e1051 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Elizabeth Green More articles by this author Ali Hajiran More articles by this author Richard Reich More articles by this author Logan Zemp More articles by this author Aymet Aydin More articles by this author Roger Li More articles by this author Michael Poch More articles by this author Wade Sexton More articles by this author Alice Yu More articles by this author Scott Gilbert More articles by this author Expand All Advertisement Loading ...