PD57-05 A RACE-STRATIFIED ANALYSIS OF THE ACCURACY OF PROSTATE MRI IN BIOPSY NAIVE MEN

Abstract

You have accessJournal of UrologyCME1 May 2022PD57-05 A RACE-STRATIFIED ANALYSIS OF THE ACCURACY OF PROSTATE MRI IN BIOPSY NAIVE MEN Julio Meza, Rilwan Babajide, Ragheed Saoud, Josephine Abelleria, Irene Helenowski, Adam Murphy, Jeanne Horowitz, and David Casalino Julio MezaJulio Meza More articles by this author , Rilwan BabajideRilwan Babajide More articles by this author , Ragheed SaoudRagheed Saoud More articles by this author , Josephine AbelleriaJosephine Abelleria More articles by this author , Irene HelenowskiIrene Helenowski More articles by this author , Adam MurphyAdam Murphy More articles by this author , Jeanne HorowitzJeanne Horowitz More articles by this author , and David CasalinoDavid Casalino More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002637.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The Prostate Imaging Reporting and Data System (PIRADS) has shown promise in improving the detection of Gleason grade group (GG) 2-5 prostate cancer (PCa) and reducing the detection of indolent GG1 PCa. However, data on the performance of PIRADS in Black and Hispanic men is sparse. We evaluated the accuracy of PIRADS version 2.0 in detecting GG2-5 PCa in White, Black, and Hispanic men. METHODS: We performed a multicenter retrospective review of biopsy-naïve Black (n=108), White (n=108), and Hispanic (n=64) men who underwent prostate biopsy (PB) following multiparametric MRI. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of PIRADS for GG2-5 PCa were calculated. Race-stratified binary logistic regression models for GG2-5 PCa using standard clinical variables and PIRADS were used to calculate area under the receiver operating characteristics curves (AUC). RESULTS: Rates of GG2-5 PCa were statistically similar between Blacks, Whites, and Hispanics (52.7% vs 42.6% vs 37.5% respectively, p=0.12). Sensitivity and NPV were lower in Hispanic men compared to White men (87.5% vs 97.8%, p=0.01; 70.0% vs 94.4%, p<0.001). NPV was lower in Black men compared to White men (84.6 vs 94.4, p=0.02). Specificity and PPV were similar in Black vs White men (21.6% vs 27.4%, p=0.32; 57.9 vs 50.0%, p=0.25) and White vs Hispanic men (27.4% vs 17.5%, p=0.14; 50.0% vs 38.9%, p=0.16).The AUCs of the PIRADS added to standard clinical data (age, PSA and suspicious prostate exam) were similar when comparing Black vs White men (0.75 vs 0.73, p=0.79) and White vs Hispanic men (0.73 vs 0.59, p=0.11). The AUCs for the Base model and PIRADS model alone were statistically similar when comparing Black vs White men and White vs Hispanic men. CONCLUSIONS: The accuracy of the PIRADS and clinical data for detecting GG2-5 PCa seems statistically similar across race. However, there is concern that PIRADS 2.0 has lower NPV in Black and Hispanic men compared to White men. Prospective validation studies are needed. Source of Funding: 1R01CA249973, National Cancer Institute © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e962 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Julio Meza More articles by this author Rilwan Babajide More articles by this author Ragheed Saoud More articles by this author Josephine Abelleria More articles by this author Irene Helenowski More articles by this author Adam Murphy More articles by this author Jeanne Horowitz More articles by this author David Casalino More articles by this author Expand All Advertisement PDF DownloadLoading ...