PD55-05 ASSOCIATION BETWEEN TRANSIENT HYDRONEPHROSIS 1 MONTH AFTER SURGERY AND RENAL FUNCTION 5 YEARS AFTER ILEAL NEOBLADDER CONSTRUCTION

Abstract

You have accessJournal of UrologyBladder Cancer: Invasive V (PD55)1 Apr 2020PD55-05 ASSOCIATION BETWEEN TRANSIENT HYDRONEPHROSIS 1 MONTH AFTER SURGERY AND RENAL FUNCTION 5 YEARS AFTER ILEAL NEOBLADDER CONSTRUCTION Takuma Nairta*, Shingo Hatakeyama, Hayato Yamamoto, Atsushi Imai, Takahiro Yoneyama, Yasuhiro Hashimoto, and Chikara Ohyama Takuma Nairta*Takuma Nairta* More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Hayato YamamotoHayato Yamamoto More articles by this author , Atsushi ImaiAtsushi Imai More articles by this author , Takahiro YoneyamaTakahiro Yoneyama More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000965.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Urinary tract obstruction and postoperative hydronephrosis are risk factors for renal function deterioration after orthotopic ileal neobladder construction. However, reports of a relationship between transient hydronephrosis and renal function are limited. Therefore, we compared the grade of postoperative hydronephrosis to renal function in patients that underwent ileal neobladder construction. METHODS: Between March 1996 and July 2013, we performed radical cystectomy and orthotopic ileal neobladder construction in 204 patients. Of these patients, 50 patients were enrolled in the study based on data availability. The hydronephrosis grade of each kidney was evaluated by computed tomography and scored on a scale grade 0 (none) to 4 (high-grade) (Fig.1A). Renal function was evaluated before and after surgery using estimated glomerular filtration rates (eGFR). The patients were divided into four groups according to their hydronephrosis grades: no, low, intermediate, and high (Fig.1B). We compared the postoperative hydronephrosis grade to renal function for five years after surgery. RESULTS: There were no significant differences in renal function before surgery among the groups. One month after surgery, the presence of hydronephrosis was significantly associated with deteriorating renal function (Fig. 2A). However, one year after surgery, hydronephrosis grades were significantly improved (Fig. 2B), and differences in renal function were not observed among the groups until five years after surgery (Fig. 2C). Multivariate logistic regression analysis showed transient hydronephrosis was not significantly associated with eGFR<60 mL/min/1.72m2 at five years after ileal neobladder construction. CONCLUSIONS: The presence of transient hydronephrosis immediately after surgery may have a limited influence on renal function five years after ileal neobladder construction. Source of Funding: This work was supported by the Japan Society for the Promotion of Science (No. 23791737, 15H02563, 15 K15579, 17 K11118, 17 K11119, 17 K16768, 17 K16770, and 17 K16771). © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1183-e1184 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Takuma Nairta* More articles by this author Shingo Hatakeyama More articles by this author Hayato Yamamoto More articles by this author Atsushi Imai More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement PDF downloadLoading ...