PD54-10 THE VALUE OF COMBINING LOW DOSE TROSPIUM CHLORIDE WITH TRANSCUTANEOUS POSTERIOR TIBIAL NERVE STIMULATION IN THE TREATMENT OF OVERACTIVE BLADDER IN FEMALES

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Female Incontinence: Therapy III1 Apr 2017PD54-10 THE VALUE OF COMBINING LOW DOSE TROSPIUM CHLORIDE WITH TRANSCUTANEOUS POSTERIOR TIBIAL NERVE STIMULATION IN THE TREATMENT OF OVERACTIVE BLADDER IN FEMALES Amr Abulseoud, Gaber Ali, Mohamed Hassouna, Ahmed Moussa, Ibrahim Ibrahim, and Emmanuel Saba Amr AbulseoudAmr Abulseoud More articles by this author , Gaber AliGaber Ali More articles by this author , Mohamed HassounaMohamed Hassouna More articles by this author , Ahmed MoussaAhmed Moussa More articles by this author , Ibrahim IbrahimIbrahim Ibrahim More articles by this author , and Emmanuel SabaEmmanuel Saba More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2420AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES This study was done to verify whether the combination of transcutaneous posterior tibial nerve stimulation (TPTNS) with low dose trospium chloride in the treatment of females with overactive bladder (OAB) would be more effective than TPTNS alone after failure of behavioral therapy. METHODS We randomized 30 women with OAB, in two groups: G I (15 patients) received 30 minutes TPTNS, three times a week; GII (15 patients) received TPTNS plus Low dose trospium chloride (20 mg once daily); all for 8 weeks. Patients were evaluated using Overactive Bladder Symptom Score questionnaire (OABSS) which includes 3 categories (score < 5 = mild symptoms, 6-11 = moderate symptoms, > 12 = severe symptoms), Incontinence Impact Questionnaire-short form 7 (IIQ-7) which includes 3 categories (score < 50% = good quality of life, 50-70% = moderate quality of life and > 70 = poor quality of life), 3 day voiding diary and urodynamics at weeks 0 and 8. RESULTS The groups were similar before treatment. After treatment both groups improved regarding all the parameters, however group II showed more significant improvement. The OABSS was reduced from 13.0 ± 1.31 to 8.53 ± 1.30 (p<0.001) and from 12.67 ± 1.95 to 10.0 ± 2.0 (p<0.001) in GII and GI respectively. Improvement (change from one category to a better one) occurred in 8 (53.3%) and in 14 (93.3%) patients in GI and GII respectively. The mean IIQ-7 was reduced from 63.38 ± 8.81 to 31.99 ± 9.26 (p<0.001) for GII vs. 64.33 ± 8.57 to 51.86 ± 17.26 (0.002) for GI. Before treatment, 11 (73.3%) and 4 (26.7%) patients in each group had moderate and poor quality of life respectively. After treatment, 6 (40%) and 14 (93.3%) had good quality of life, 7 (46.7%) and 1 (6.7%) had moderate quality of life in GI and GII respectively. Two (13.3%) in GI had poor quality of life. The mean frequency for GII after treatment was 8.60 ± 0.83 instead of 12.87 ± 1.85 (p<0.001) before treatment, while it was reduced from 13.13 ± 1.64 to 10.60 ± 2.32 (p=0.003) in GI. The cystometric capacity improved from 263.40 ± 50.45 ml to 377.80 ± 112.92 ml (p=0.001) for GII Vs. 250.13 ± 56.24 ml to 296.40 ± 99.0 ml (p=0.026) for GI. CONCLUSIONS TPTNS combined with low dose trospium chloride proved to be more effective than TPTNS alone in the treatment of OAB in females. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1049 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Amr Abulseoud More articles by this author Gaber Ali More articles by this author Mohamed Hassouna More articles by this author Ahmed Moussa More articles by this author Ibrahim Ibrahim More articles by this author Emmanuel Saba More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...