PD54-08 EX-VIVO EXPERIMENTAL 7 TESLA HIGH RESOLUTION MAGNETIC RESONANCE IMAGING - OF LOCALIZED PROSTATE CANCER

Abstract

INTRODUCTION AND OBJECTIVE: 1.5T or 3T MRI of the prostate is the most effective imaging for the detection of prostate cancer. We have been working on ex vivo experimental models of high-resolution 7T MRI to improve resolution and tumour detection. METHODS: This work focused on the experimental 7T MRI study (Bruker Biospin, Billerica, MA, MA, USA) of whole prostate glands of patients operated on for prostate cancer. The imagery included T2 sequences (TurboRARE-3D), at the highest resolution of 130 X130 X195 m3 and diffusion with ADC mapping. The qualitative morphological evaluation was carried out blindly by two independent reviewers according to predefined criteria. The tumour lesion sensitivity analysis was compared with the corresponding final histology. Intra-class correlation tests and Spearman's coefficient were used for the concordance of quality interpretation between reviewers. The diagnostic lesion performance was analyzed according to 6 sectors. RESULTS: The high resolution of the images (Fig 1), compared to that obtained by histo-pathological analysis, was considered good with a high inter-reviewer agreement (Tab 1). The pathology-imaging correlation study for cancer detection with sector analysis showed a sensitivity of 70%, specificity of 80%, positive predictive value of 79% and negative predictive value of 72% (Fig 2). CONCLUSIONS: These results made it possible to measure the resolution of MRI imaging at 7T ex vivo and its interest in cancer detection. A 7T MRI semiology of the prostate tissue should still be described. These images can be used as a basis for the future in vivo translation of current imaging to 7T MRI.Source of Funding: None